ISLAMABAD: A natural compound found in strawberries and other fruits and vegetables could help to prevent Alzheimer's disease and other age-related neurodegenerative diseases, new research suggests.For the new study, Maher and team sought to determine whether fisetin might have benefits for sporadic Alzheimer's disease, which is the most common form that arises with age.
To reach their findings, the researchers tested fisetin in mice that had been genetically engineered to age prematurely, resulting in a mouse model of sporadic Alzheimer's disease.
When the prematurely aging mice were 3 months old, they were divided into two groups. One group was fed a dose of fisetin with their food every day for 7 months, until they reached the age of 10 months. The other group did not receive the compound.
All rodents were subject to cognitive and behavioral tests throughout the study, and the researchers also assessed the mice for levels of markers linked to stress and inflammation.
The researchers found that the 10-month-old mice that did not receive fisetin showed an increase in markers associated with stress and inflammation, and they also performed significantly worse in cognitive tests than mice that were treated with fisetin.
The researchers believe that their findings indicate that fisetin may lead to a new preventive strategy for Alzheimer's, as well as other age-related neurodegenerative diseases.
"Based on our ongoing work, we think fisetin might be helpful as a preventative for many age-associated neurodegenerative diseases, not just Alzheimer's, and we'd like to encourage more rigorous study of it," says Maher.
However, the researchers note that human clinical trials are required to confirm their results. They hope to team up with other investigators to meet this need.